Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements.

@article{Young2007CentralRO,
  title={Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements.},
  author={Hays W. J. Young and Olatunji W. Williams and Divay Chandra and Lindsey K. Bellinghausen and Guillermina Font P{\'e}rez and Alberto Su{\'a}rez and Michael J. Tuvim and Michelle Roy and Samantha N. Alexander and Seyed Javad Mirhassani Moghaddam and Roberto Adachi and Michael R. Blackburn and Burton F Dickey and Christopher M Evans},
  journal={American journal of respiratory cell and molecular biology},
  year={2007},
  volume={37 3},
  pages={273-90}
}
Mucus hypersecretion contributes to morbidity and mortality in many obstructive lung diseases. Gel-forming mucins are the chief glycoprotein components of airway mucus, and elevated expression of these during mucous metaplasia precedes the hypersecretory phenotype. Five orthologous genes (MUC2, MUC5AC, MUC5B, MUC6, and MUC19) encode the mammalian gel-forming mucin family, and several have been implicated in asthma, cystic fibrosis, and chronic obstructive pulmonary disease pathologies. However… CONTINUE READING