Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells.

@article{Ohtsu2008CentralRO,
  title={Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells.},
  author={Haruhiko Ohtsu and Sadaharu Higuchi and Heigoro Shirai and Kunie Eguchi and Hiroyuki Suzuki and Akinari Hinoki and Eugen Brailoiu and Andrea D. Eckhart and Gerald Frank and Satoru Eguchi},
  journal={Endocrinology},
  year={2008},
  volume={149 7},
  pages={3569-75}
}
The angiotensin II (AngII) type 1 receptor (AT(1)) plays a critical role in hypertrophy of vascular smooth muscle cells (VSMCs). Although it is well known that G(q) is the major G protein activated by the AT(1) receptor, the requirement of G(q) for AngII-induced VSMC hypertrophy remains unclear. By using cultured VSMCs, this study examined the requirement of G(q) for the epidermal growth factor receptor (EGFR) pathway, the Rho-kinase (ROCK) pathway, and subsequent hypertrophy. AngII-induced… CONTINUE READING

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