Central respiratory effects versus neuromuscular actions of nerve agents.

@article{Rickett1986CentralRE,
  title={Central respiratory effects versus neuromuscular actions of nerve agents.},
  author={D. Rickett and John E. Foster Glenn and E T Beers},
  journal={Neurotoxicology},
  year={1986},
  volume={7 1},
  pages={225-36}
}
The relative contributions of peripheral neuromuscular and central nervous system components in the respiratory failure following acute exposure to organophosphorous anticholinesterase (AChE) agents remain unclear. We examined the effects of the nerve agents, soman, sarin, tabun, and VX on diaphragm contraction, diaphragm electromyogram (EMG), phrenic nerve activity, medullary respiratory-related unit activity, and airflow in the cat. The agents were infused at the rate of 1 LD50 per 15 minutes… CONTINUE READING
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