Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion.

@article{Vzquez2008CentralRR,
  title={Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion.},
  author={Mar{\'i}a de Jes{\'u}s P{\'e}rez V{\'a}zquez and Carmen Ruth Gonz{\'a}lez and L P{\'e}rez Varela and Ricardo Lage and S. {\'O}scar Tovar and Susana Sangiao-Alvarellos and Lynda M. Williams and Antonio Vidal-Puig and Rub{\'e}n Nogueiras and Miguel Lopez and Carlos Di{\'e}guez},
  journal={Endocrinology},
  year={2008},
  volume={149 9},
  pages={4534-43}
}
Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms. Here, we demonstrate that the anorectic effect of RSTN is associated with inappropriately decreased mRNA expression of orexigenic (agouti-related protein and neuropeptide Y) and increased mRNA expression of anorexigenic (cocaine and amphetamine-regulated transcript) neuropeptides in the arcuate nucleus of the… CONTINUE READING
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