Central processing of leg proprioception in Drosophila

@article{Agrawal2020CentralPO,
  title={Central processing of leg proprioception in Drosophila},
  author={Sweta Agrawal and Evyn S. Dickinson and Anne Sustar and Pralaksha Gurung and David Shepherd and James W. Truman and John C. Tuthill},
  journal={eLife},
  year={2020},
  volume={9}
}
Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features of body kinematics. Although proprioceptive feedback is crucial for accurate motor control, little is known about how downstream circuits transform limb sensory information to guide motor output. Here, we investigate neural circuits in Drosophila that process proprioceptive information from the fly leg. We identify three cell-types from distinct developmental lineages that… 
View on PubMed
doi.org
19 Citations
Highly Influential Citations
1
Background Citations
8
Methods Citations
3
Results Citations
1

19 Citations

Functional architecture of neural circuits for leg proprioception in Drosophila

Functional architecture of neural circuits for leg proprioception in Drosophila

Biomechanical origins of proprioceptive maps in the Drosophila leg

This work finds that proprioceptor neurons in the Drosophila femur are organized into functional groups that are biomechanically specialized to detect features of tibia joint kinematics.

Sustained spinal motor activity triggered by direct mechanosensory stimulation in adult Drosophila melanogaster

Light is shed on the ability of specific sensory circuits to modulate motor control, including initiation of movement, and how this information can be automatically translated to a motor command by spinal neuronal pathways.

A leg to stand on: computational models of proprioception.

Non-linear multimodal integration in a distributed premotor network controls proprioceptive reflex gain in the insect leg

The two-body problem: Proprioception and motor control across the metamorphic divide

Ascending neurons convey behavioral state to integrative sensory and action selection centers in the brain

Quantitative, deep network-based neural and behavioral analyses revealed that ascending populations convey high-level behavioral state signals almost exclusively to brain regions implicated in sensory feature contextualization and action selection.

Load Non-Linearly Modulates Movement Reflex Gain in an Insect Leg via a Distributed Network of Identified Nonspiking Interneurons

Findings show how gain changes can allow premotor networks to integrate multiple sensory modalities and thus generate context-appropriate motor activity.

Haltere and visual inputs sum linearly to predict wing (but not gaze) motor output in tethered flying Drosophila

This work introduces an experimental paradigm for reproducibly altering haltere stroke kinematics and uses it to quantify multisensory integration of wing and gaze equilibrium reflexes, and shows that multisENSory wing-steering responses reflect a linear superposition of haltere-driven and visually driven responses, but that mult isensory gaze responses are not well predicted by this framework.

References

SHOWING 1-10 OF 120 REFERENCES

Neural Coding of Leg Proprioception in Drosophila

A size principle for leg motor control in Drosophila

Using in vivo calcium imaging and electrophysiology, it is found that genetically-identified motor neurons controlling flexion of the fly tibia exhibit a gradient of anatomical, physiological, and functional properties consistent with the size principle.

Mechanosensory Feedback in Walking: From Joint Control to Locomotor Patterns

A size principle for recruitment of Drosophila leg motor neurons

This work uses in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia and reveals the functional organization of the fly leg motor system.

The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force.

Proprioceptive senses, particularly of limb position and movement, deteriorate with age and are associated with an increased risk of falls in the elderly and the more recent information available on proprioception has given a better understanding of the mechanisms underlying these senses.

Six-legged walking in insects: how CPGs, peripheral feedback, and descending signals generate coordinated and adaptive motor rhythms.

The role of central pattern generating networks (CPGs) and their contribution to the generation of six-legged walking in insects is reviewed with a particular focus on the role of CPGs in intersegmental coordination.

Load sensing and control of posture and locomotion.

Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster

Surprisingly, it is found that inactivation of sensory neurons in the fly's legs, to block proprioceptive feedback, led to deficient step precision, but interleg coordination and the ability to execute a tripod gait were unaffected.

Recovery of locomotion after injury in Drosophila melanogaster depends on proprioception

It is suggested that proprioceptive input from the intact limbs plays a crucial role in the behavioral plasticity associated with locomotor recovery after injury, and a minimal mathematical model that links neurodynamics to body mechanics during walking shows that redistributing leg forces between the right and left side enables recovery.

Nonspiking local interneurons in insect leg motor control. I. Common layout and species-specific response properties of femur-tibia joint control pathways in stick insect and locust.

Evidence is obtained that the neuronal networks that control the femur-tibia joints in the two species consist of morphologically and physiologically similar--and thus probably homologous--interneurons, which drive the same pools of leg motoneurons in both species.
...