Central precocious puberty caused by mutations in the imprinted gene MKRN3.

@article{Abreu2013CentralPP,
  title={Central precocious puberty caused by mutations in the imprinted gene MKRN3.},
  author={Ana Paula Abreu and Andrew Dauber and Delanie Bulc{\~a}o Macedo and Sekoni D. Noel and Vinicius Nahime Brito and John C. Gill and Priscilla Cukier and I. Richard Thompson and V{\'i}ctor M. Navarro and Priscila Gagliardi and T{\^a}nia Lemos Coelho Rodrigues and Cristiane Kochi and Carlos Alberto Longui and Dominique Beckers and Francis de Zegher and Luciana Ribeiro Montenegro and Berenice B Mendonca and Rona S. Carroll and Joel N Hirschhorn and Ana Claudia Latronico and Ursula Brigitte Kaiser},
  journal={The New England journal of medicine},
  year={2013},
  volume={368 26},
  pages={
          2467-75
        }
}
BACKGROUND The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic-pituitary-gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factors, but only a few, rare molecular defects associated with central precocious puberty have been identified. METHODS We performed whole-exome sequencing in 40 members of 15 families with central… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 140 CITATIONS, ESTIMATED 58% COVERAGE

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 17 Highly Influenced Citations

  • Averaged 20 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES