Central origin of IL-1beta produced during peripheral inflammation: role of meninges.

@article{Garabedian2000CentralOO,
  title={Central origin of IL-1beta produced during peripheral inflammation: role of meninges.},
  author={B{\'e}atrice Vernet-der Garabedian and Yolande Lemaigre-Dubreuil and Jean Mariani},
  journal={Brain research. Molecular brain research},
  year={2000},
  volume={75 2},
  pages={259-63}
}
Brain expression of Interleukin-1beta (IL-1beta) and its modulation have been extensively documented in different animal models. The majority of the studies were based on techniques such as RT-PCR, RIA and ELISA using global extracts. Meningeal tissue or choroid plexus both belong to the peripheral compartment. Thus, their presence in nervous tissue extracts may lead to erroneous interpretations. We measured IL-1beta mRNA in the cerebellum, hippocampus and cerebral cortex collected with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

A role for human brain pericytes in neuroinflammation

Journal of Neuroinflammation • 2013
View 18 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…