Central noradrenergic mechanisms underlying acute stress responses of the Hypothalamo-pituitary-adrenal axis: Adaptations through pregnancy and lactation

@article{Douglas2005CentralNM,
  title={Central noradrenergic mechanisms underlying acute stress responses of the Hypothalamo-pituitary-adrenal axis: Adaptations through pregnancy and lactation},
  author={Alison J. Douglas},
  journal={Stress},
  year={2005},
  volume={8},
  pages={18 - 5}
}
Hypothalamo-pituitary-adrenal axis responses to stress are attenuated perinatally, and may contribute towards conservation of energy stores and/or prevention of overexposure to glucocorticoid and its adverse effects in the developing fetus/neonate. Previous work has shown that reduced central drive to the hypothalamo-pituitary-adrenal axis is responsible, since parvocellular paraventricular nucleus neurone responses are reduced. One of the main input pathways to the paraventricular nucleus that… 

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References

SHOWING 1-10 OF 167 REFERENCES

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.

  • D. Jessop
  • Biology, Medicine
    The Journal of endocrinology
  • 1999
TLDR
The HPA axis is subject to mechanisms of tonic inhibition which operate independently of glucocorticoids, and cumulative evidence is compelling for the existence of compounds acting on CRH and/or AVP expression within the PVN.

Central non-glucocorticoid inhibitors of the hypothalamo – pituitary – adrenal axis

TLDR
The HPA axis is subject to mechanisms of tonic inhibition which operate independently of glucocorticoids, and cumulative evidence is compelling for the existence of compounds acting on CRH and/or AVP expression within the PVN.

Neuroendocrine pharmacology of stress.

Reduced Noradrenergic Tone to the Hypothalamic Paraventricular Nucleus Contributes to the Stress Hyporesponsiveness of Lactation

TLDR
The data suggest that the secretion of NA in the PVN is reduced during lactation, and that the ability of PVN parvocellular neurons to respond to changes in synaptic NA levels (i.e. after stress) is also altered.

Reduced Activity of the Noradrenergic System in the Paraventricular Nucleus at the End of Pregnancy: Implications for Stress Hyporesponsiveness

TLDR
In late pregnancy, there is reduced noradrenergic input to the paraventricular nucleus and reduced α1A‐receptor expression in the parvocellular nucleus, both of which may contribute to the reduced responsiveness of the HPA axis in pregnancy.

No stress response of the hypothalamo-pituitary-adrenal axis in parturient rats: lack of involvement of brain oxytocin.

TLDR
The reactivity of the HPA axis to external stressors is strongly attenuated during parturition, and this cannot be disinhibited by blocking the receptor-mediated action of brain oxytocin.

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

...