Central noradrenaline depletion antagonizes aspects ofd-amphetamine-induced hyperactivity in the rat

Abstract

The effects of noradrenaline (NA) depletion upon amphetamine-induced hyperactivity were examined in five experiments. Central NA depletion via either systemic DSP4 or neonatal 6-OHDA antagonised the amphetamine-induced (2 mg/kg SC) increase in rearing behaviour, whereas lesions of the dorsal noradrenergic bundle using 6-hydroxydopamine antagonised the… (More)
DOI: 10.1007/BF00652230

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