Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects.

@article{Cheng2011CentralNA,
  title={Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects.},
  author={Pei-Wen Cheng and Pei-Jung Frank Lu and Siang-Ru Chen and Wen-Yu Ho and Wen-Han Cheng and L Z Hong and Tung-Chen Yeh and Gwo-Ching Sun and Ling-lin Wang and Michael Hsiao and Ching-Jiunn Tseng},
  journal={British journal of pharmacology},
  year={2011},
  volume={163 6},
  pages={1203-13}
}
BACKGROUND AND PURPOSE Recent evidence has suggested that nicotine decreases blood pressure (BP) and heart rate (HR) in the nucleus tractus solitarii (NTS), indicating that nicotinic acetylcholine receptors (nAChRs) play an important role in BP control in the NTS. However, the signalling mechanisms involved in nAChR-mediated depressor effects in the NTS are unclear. Hence, the aim of this study was to investigate these signalling mechanisms. EXPERIMENTAL APPROACH Depressor responses to… CONTINUE READING

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