Central neuroplasticity and pathological pain.

  title={Central neuroplasticity and pathological pain.},
  author={Ronald Melzack and Terence J. Coderre and Joel Katz and Anthony L Vaccarino},
  journal={Annals of the New York Academy of Sciences},
The traditional specificity theory of pain perception holds that pain involves a direct transmission system from somatic receptors to the brain. The amount of pain perceived, moreover, is assumed to be directly proportional to the extent of injury. Recent research, however, indicates far more complex mechanisms. Clinical and experimental evidence shows that noxious stimuli may sensitize central neural structures involved in pain perception. Salient clinical examples of these effects include… CONTINUE READING


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