Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75.

@article{Peterson1999CentralNL,
  title={Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75.},
  author={Daniel A Peterson and Heather Dickinson-Anson and John T Leppert and K F Lee and Fred H. Gage},
  journal={The Journal of comparative neurology},
  year={1999},
  volume={404 1},
  pages={
          1-20
        }
}
The neurotrophin receptor p75 is a low-affinity receptor that binds neurotrophins. To investigate the role of p75 in the survival and function of central neurons, p75 null-mutant and wild type litter mate mice were tested on behavioral tasks. Null mutants showed significant performance deficits on water maze, inhibitory avoidance, motor activity, and habituation tasks that may be attributed to cognitive dysfunction or may represent a global sensorimotor impairment. The p75 null-mutant and wild… CONTINUE READING

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