Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway.

@article{Huang2010CentralNA,
  title={Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway.},
  author={Bing S. Huang and Sara Ami Ahmadi and Monir Ahmad and Roselyn A. White and Frans H H Leenen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 2},
  pages={
          H422-30
        }
}
An increase in plasma ANG II causes neuronal activation in hypothalamic nuclei and a slow pressor response, presumably by increasing sympathetic drive. We evaluated whether the activation of a neuromodulatory pathway, involving aldosterone and "ouabain," is involved in these responses. In Wistar rats, the subcutaneous infusion of ANG II at 150 and 500 ng x kg(-1) x min(-1) gradually increased blood pressure up to 60 mmHg at the highest dose. ANG II at 500 ng x kg(-1) x min(-1) increased plasma… 
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