Central nervous system toxicity of high-dose systemic cytosine arabinoside.

Abstract

Forty-nine adult patients with acute leukemia in relapse, refractory to conventional therapy, were studied. Increasing quantities of i.v. bolus high-dose cytosine arabinoside (cytarabine) were administered using the following schedules: 3 g/m2 every 12 hrs for 4-16 consecutive doses, or 4.5 g/m2 every 12 hrs for 12 consecutive doses. Patients ages ranged 16… (More)

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@article{Lazarus1981CentralNS, title={Central nervous system toxicity of high-dose systemic cytosine arabinoside.}, author={Hillard M Lazarus and R. H. Herzig and G. P. Herzig and Gordon L. Phillips and Uros Roessmann and David J Fishman}, journal={Cancer}, year={1981}, volume={48 12}, pages={2577-82} }