Central nervous system toxicity associated with concurrent use of triazolam and cimetidine.

@article{Britton1985CentralNS,
  title={Central nervous system toxicity associated with concurrent use of triazolam and cimetidine.},
  author={Mark L. Britton and E S Waller},
  journal={Drug intelligence & clinical pharmacy},
  year={1985},
  volume={19 9},
  pages={666-8}
}
A 49-year-old woman treated with cimetidine 300 mg tid for more than 18 months for Zollinger-Ellison syndrome experienced lethargy, dizziness, ataxia, and auditory and visual hallucinations after receiving triazolam 0.375 mg hs for sleep. Triazolam plasma concentrations were measured, and a triazolam elimination half-life was calculated to be approximately 8 hours (reported range 1.7-3 h). Cimetidine has been reported to decrease the apparent oral clearance of triazolam, resulting in increased… CONTINUE READING

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A 49-year - old woman treated with cimetidine 300 mg tid for more than 18 months for Zollinger - Ellison syndrome experienced lethargy , dizziness , ataxia , and auditory and visual hallucinations after receiving triazolam 0.375 mg hs for sleep .
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