Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior.

@article{Zhao2008CentralNS,
  title={Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior.},
  author={Liping Zhao and Ki Woo Kim and Yayoi Ikeda and Kimberly K Anderson and Laurel Amanda Beck and Stephanie Chase and Stuart A Tobet and Keith L. Parker},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 6},
  pages={1403-15}
}
Steroidogenic factor 1 (SF-1) plays key roles in adrenal and gonadal development, expression of pituitary gonadotropins, and development of the ventromedial hypothalamic nucleus (VMH). If kept alive by adrenal transplants, global knockout (KO) mice lacking SF-1 exhibit delayed-onset obesity and decreased locomotor activity. To define specific roles of SF-1 in the VMH, we used the Cre-loxP system to inactivate SF-1 in a central nervous system (CNS)-specific manner. These mice largely… CONTINUE READING

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