Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.

@article{Lazarus2006CentralNS,
  title={Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.},
  author={Hillard M Lazarus and S. M. Richards and Raj Chopra and Mark R Litzow and Alan K. Burnett and Peter H. Wiernik and Ian M Franklin and Martin S. Tallman and Lucy B M Cook and Georgina A N Buck and I Jill Durrant and Jacob M. Rowe and Anthony H. Goldstone},
  journal={Blood},
  year={2006},
  volume={108 2},
  pages={465-72}
}
Outcome of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) disease at diagnosis is unclear. We treated 1508 de novo ALL patients with 2-phase induction and then high-dose methotrexate with l-asparaginase. Patients up to 50 years old in first remission (CR1) with a matched related donor (MRD) underwent an allogeneic stem cell transplantation (SCT); the remainder in CR1 were randomized to an autologous SCT or intensive consolidation followed by maintenance… CONTINUE READING
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