Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis

@inproceedings{Braun2011CentralNS,
  title={Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis},
  author={Theodore P. Braun and Xinxia Zhu and Marek Szumowski and Gregory David Scott and Aaron J Grossberg and Peter R. Levasseur and Kathryn F. Graham and Sheehan Khan and Sambasivarao Damaraju and William F. Colmers and Vickie Baracos and Daniel L Marks},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of systemic inflammation. Although direct inflammatory cytokine action on muscle promotes atrophy, nonmuscle sites of action for inflammatory mediators are less well described. We demonstrate that central nervous system (CNS)-delimited interleukin 1β (IL-1β) signaling alone can evoke a catabolic program in muscle, rapidly inducing atrophy. This effect is dependent on hypothalamic-pituitary-adrenal (HPA) axis… CONTINUE READING
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