Central nervous system infection in congenital syphilis.

@article{Michelow2002CentralNS,
  title={Central nervous system infection in congenital syphilis.},
  author={Ian C. Michelow and George D. Wendel and Michael V. Norgard and Fiker Zeray and Nora Kristine Leos and Rajiha Alsaadi and Pablo J. S{\'a}nchez},
  journal={The New England journal of medicine},
  year={2002},
  volume={346 23},
  pages={1792-8}
}
BACKGROUND Identification of infants with Treponema pallidum infection of the central nervous system remains challenging. METHODS We used rabbit-infectivity testing of the cerebrospinal fluid to detect T. pallidum infection of the central nervous system in infants born to mothers with syphilis. The results were compared with those of clinical, radiographic, and conventional laboratory evaluations; IgM immunoblotting of serum and cerebrospinal fluid; polymerase-chain-reaction (PCR) assay… CONTINUE READING