Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease

@article{Richard2000CentralNS,
  title={Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease},
  author={St{\'e}phane Richard and Ph. David and Kathlyn Marsot-Dupuch and Sophie Giraud and Christophe B{\'e}roud and François Resche},
  journal={Neurosurgical Review},
  year={2000},
  volume={23},
  pages={1-22}
}
Von Hippel-Lindau disease (VHL) is a hereditary cancer syndrome caused by germline mutations of the VHL tumor suppressor gene. Major progress has been made in the last decade in both clinical and fundamental aspects of VHL. The VHL gene product, pVHL, has major and multiple functions: pVHL regulates not only first angiogenesis but also extracellular matrix formation and the cell cycle. A molecular diagnosis of VHL is now available, leading to a transformation in clinical management of patients… CONTINUE READING
49 Citations
150 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 150 references

Opinion of patients with VHL disease towards presymptomatic genetic testing for their children and prenatal diagnosis

  • M Lévy, S Richard
  • J Med Genet
  • 2000

Similar Papers

Loading similar papers…