Central nervous system excitatory effects of meperidine in cancer patients

@article{Kaiko1983CentralNS,
  title={Central nervous system excitatory effects of meperidine in cancer patients},
  author={R. Kaiko and K. Foley and P. Grabinski and G. Heidrich and A. Rogers and C. Inturrisi and M. Reidenberg},
  journal={Annals of Neurology},
  year={1983},
  volume={13}
}
The analgesic meperidine has been reported to produce signs of central nervous system excitation in human beings. To determine the relationship between signs and symptoms of central nervous system excitation and plasma levels of meperidine and normeperidine, we studied 67 patients receiving meperidine for the relief of postoperative or chronic pain. In 48 patients, excitatory effects ranging from mild nervousness to tremors, twitches, multifocal myoclonus, and seizures were directly correlated… Expand
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