Central nervous system effects of natural and synthetic glucocorticoids

@article{Fietta2009CentralNS,
  title={Central nervous system effects of natural and synthetic glucocorticoids},
  author={Pierluigi Fietta and P. Fietta and G. Delsante},
  journal={Psychiatry and Clinical Neurosciences},
  year={2009},
  volume={63}
}
Natural glucocorticoids (NGC) physiologically modulate body homeostasis and coordinate adaptive responses to stress, involving almost all organs and tissues, including brain. Since their therapeutic availability, synthetic GC (SGC) have been successfully prescribed for a variety of diseases. Mounting evidence, however, demonstrated pleiotropic adverse effects (AE), including central nervous system (CNS) disturbances, which are often misdiagnosed or underestimated. The aim of the present study… Expand
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References

SHOWING 1-10 OF 112 REFERENCES
Glucocorticoids and brain functions.
TLDR
The main effects of glucocorticoids on brain functions are discussed and the main mechanisms of action, however, with different kinetics and/or receptor affinities are reviewed. Expand
Glucocorticoid effects on memory function over the human life span
TLDR
Evidence from in vitro studies of synaptic and cell function and evidence from animals indicating the GCs can regulate substrates of memory function is extended, suggesting the use of safe and effective agents for blocking adverse GC effects on brain functions including memory may offer benefits to individuals suffering acute and chronic stressors and could prevent brain changes relevant to stress, aging, and stress-related neuropsychiatric diseases. Expand
Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids
  • O. Wolkowitz
  • Medicine, Psychology
  • Psychoneuroendocrinology
  • 1994
TLDR
The preliminary data raise the possibility that the behavioral effects of exogenous corticosteroids have specific neural concomitants and that the pattern of biological changes produced contributes to the behavioral variability observed. Expand
Glucocorticoid-induced impairment in declarative memory performance in adult humans
TLDR
Investigation of the cognitive consequences of DEX treatment in normal adult human subjects hypothesizing a decrease in declarative memory performance after extended but not overnight treatment found correct paragraph recall improved over the course of treatment, consistent with practice. Expand
Action of Glucocorticoids on Survival of Nerve Cells: Promoting Neurodegeneration or Neuroprotection? 1
TLDR
Different aspects of the complex role of GCs in neurodegeneration and neuroprotection are addressed, such as concentration dependent actions ofGCs on neuronal viability, anatomical diversity of GC‐mediated mechanisms in the brain and species and strain differences in GC‐induced neurodegenersation. Expand
Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease.
TLDR
The interpretation is offered that glucocorticoid-mediated regulation of glucose transport is altered in AD, and this may underlie both the hippocampal insensitivity to cortisol and the failure in these patients to mount a peripheral glucose response. Expand
Prednisone effects on neurochemistry and behavior. Preliminary findings.
TLDR
Prednisone administration was associated with decreases in cerebrospinal fluid levels of corticotropin, norepinephrine, beta-endorphin,beta-lipotropic hormone, and somatostatinlike immunoreactivity, andCorrelations between the neurochemical and behavioral changes are discussed. Expand
Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease.
TLDR
Several animal studies have shown that prenatal glucocorticoid excess, either from endogenous overproduction with maternal stress or through exogenous administration to the mother or fetus, reduces birth weight and causes lifelong hypertension, hyperglycaemia and behavioural abnormality in the offspring, which suggests an epigenetic mechanism. Expand
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TLDR
This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor. Expand
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
TLDR
It is reported that GCs can selectively activate Trk receptor tyrosine kinases after in vivo administration in the brain and in cultures of hippocampal and cortical neurons, resulting in neuroprotection of neurons deprived of trophic support. Expand
...
1
2
3
4
5
...