Central nervous system effects of caffeine and adenosine on fatigue.

  title={Central nervous system effects of caffeine and adenosine on fatigue.},
  author={J. Mark Davis and Zuowei Zhao and Howard S. Stock and Kristen A. Mehl and James Buggy and Gregory A. Hand},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={284 2},
  • J. DavisZuowei Zhao G. Hand
  • Published 1 February 2003
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. This study was designed to test the hypothesis that blockade of central nervous system (CNS) adenosine receptors may explain the beneficial effect of caffeine on fatigue. Initial experiments were done to confirm an effect of CNS caffeine and/or the adenosine A(1)/A(2) receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) on spontaneous locomotor activity. Thirty minutes before measurement of spontaneous… 

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