Central nervous system effects of acetate: contribution to the central effects of ethanol.

@article{Carmichael1991CentralNS,
  title={Central nervous system effects of acetate: contribution to the central effects of ethanol.},
  author={F J Lou Carmichael and Yedy Israel and Matthew Crawford and Kanwal J Minhas and Victor R Saldivia and Susannah K Sandrin and P. Campisi and H{\'e}ctor M. Orrego},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={259 1},
  pages={403-8}
}
Acetate, resulting from ethanol metabolism in the liver, is released into the circulation and is utilized in a number of tissues, including the brain. In its metabolism, acetate leads to the production of adenosine, a powerful physiological mediator. We have investigated the effect of acetate on central nervous system (CNS) function in rodents. Sodium acetate in doses resulting in blood concentrations comparable to those attained after the administration of 1 to 2 g/kg ethanol, had significant… CONTINUE READING

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