Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms.

@article{McDonald2010CentralNS,
  title={Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms.},
  author={Claire L. McDonald and Julia L. Newton and Hei Ming Lai and Stuart N. Baker and David E. J. Jones},
  journal={Journal of hepatology},
  year={2010},
  volume={53 6},
  pages={1095-100}
}
BACKGROUND & AIMS Primary biliary cirrhosis (PBC) is associated with fatigue, memory impairment, and sleep disturbances. These symptoms suggest the possibility of underlying central nervous system (CNS) dysfunction. During exercise, fatigue develops due to muscular processes (peripheral fatigue) and decreased neurological activation of the muscle (central fatigue). In this study we objectively quantify central and peripheral fatigue in PBC and investigate the integrity of cortical inhibitory… CONTINUE READING

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