Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production

@article{MartnezSernndez2012CentralNS,
  title={Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production},
  author={Victoria Mart{\'i}nez-Sern{\'a}ndez and Adolfo Figueiras},
  journal={Journal of Neurology},
  year={2012},
  volume={260},
  pages={1951-1959}
}
The etiology of multiple sclerosis has not yet been fully described. A potential link between the recombinant hepatitis B vaccine and an increased risk of onset or exacerbation of multiple sclerosis emerged in the mid-1990s, leading to several spontaneous reports and studies investigating this association. We conducted a critical systematic review aimed at assessing whether hepatitis B vaccination increases the risk of onset or relapse of multiple sclerosis and other central nervous system… 
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Evidence from studies investigating the association between administration of hepatitis B vaccine and onset or relapse of multiple sclerosis and other demyelinating diseases is presented.
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