Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.

@article{OchoaRepraz2010CentralNS,
  title={Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.},
  author={Javier Ochoa-Rep{\'a}raz and Daniel W. Mielcarz and Lauren E. Ditrio and Ashley R. Burroughs and Sakhina Begum-Haque and Suryasarathi Dasgupta and Dennis L Kasper and Lloyd H. Kasper},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={4101-8}
}
The importance of gut commensal bacteria in maintaining immune homeostasis is increasingly understood. We recently described that alteration of the gut microflora can affect a population of Foxp3(+)T(reg) cells that regulate demyelination in experimental autoimmune encephalomyelitis (EAE), the experimental model of human multiple sclerosis. We now extend our previous observations on the role of commensal bacteria in CNS demyelination, and we demonstrate that Bacteroides fragilis producing a… CONTINUE READING
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