Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

@article{Toggas1994CentralNS,
  title={Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.},
  author={Stephanie M. Toggas and Eliezer Masliah and Edward M. Rockenstein and Glenn F Rall and Carmela R. Abraham and Lennart Mucke},
  journal={Nature},
  year={1994},
  volume={367 6459},
  pages={188-93}
}
Many people infected with human immunodeficiency virus type 1 (HIV-1) develop neurological complications that can culminate in dementia and paralysis. The discrepancy between the severity of impairment and the paucity of detectable HIV-1 within neurons has led to an intense search for diffusible virus- and host-derived factors that might be neurotoxic (see ref. 2 for review). The HIV-1 envelope glycoprotein gp120 is an extracellular protein that is shed from infected cells and so has the… CONTINUE READING
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