Central nervous system blockade by peripheral administration of AT1 receptor blockers.

Abstract

After peripheral administration, AT(1) receptor blockers appear to be able to enter the brain and cause AT(1) receptor blockade in the central nervous system. In the current study, we investigated the effects of subcutaneous administration of embusartan versus losartan on inhibition of AT(1) receptor binding in rat brain by in vitro autoradiography. At 4… (More)

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Cite this paper

@article{Wang2003CentralNS, title={Central nervous system blockade by peripheral administration of AT1 receptor blockers.}, author={Jun Wang and Junhui Tan and Frans H H Leenen}, journal={Journal of cardiovascular pharmacology}, year={2003}, volume={41 4}, pages={593-9} }