Central nervous system atrophy and clinical status in multiple sclerosis.

@article{Zivadinov2004CentralNS,
  title={Central nervous system atrophy and clinical status in multiple sclerosis.},
  author={Robert Zivadinov and Rohit Bakshi},
  journal={Journal of neuroimaging : official journal of the American Society of Neuroimaging},
  year={2004},
  volume={14 3 Suppl},
  pages={
          27S-35S
        }
}
In this review, the authors focus on clinical aspects of central nervous system (CNS) atrophy in multiple sclerosis (MS), including the relationship between atrophy and disability, disease course, disease duration, quality of life, and fatigue. Cross-sectional studies have demonstrated a moderate but significant correlation between brain or spinal cord atrophy and physical disability in patients with MS. Longitudinal studies (>/= 5 years) have shown that CNS atrophy is a significant predictor… CONTINUE READING

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