Central nervous system Gαi2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway.

@article{Kapusta2013CentralNS,
  title={Central nervous system Gαi2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway.},
  author={Daniel R. Kapusta and Crissey L. Pascale and Jill T. Kuwabara and Richard David Wainford},
  journal={Hypertension},
  year={2013},
  volume={61 2},
  pages={368-75}
}
In salt-resistant phenotypes, chronic elevated dietary sodium intake evokes suppression of renal sodium-retaining mechanisms to maintain sodium homeostasis and normotension. We have recently shown that brain Gαi(2) protein pathways are required to suppress renal sympathetic nerve activity and facilitate maximal sodium excretion during acute intravenous volume expansion in Sprague-Dawley rats. Here, we studied the role of brain Gαi(2) proteins in the endogenous central neural mechanisms acting… CONTINUE READING
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