Central nervous effects of the convulsant protein canatoxin.

  title={Central nervous effects of the convulsant protein canatoxin.},
  author={C{\'e}lia Regina Carlini and Cecilia Gomes and J. A. Guimar{\~a}es and Regina P Markus and Hiroyuki Sato and Gustaf Trolin},
  journal={Acta pharmacologica et toxicologica},
  volume={54 3},
Some pharmacological-toxicological effects of canatoxin, a toxic protein purified from the seeds of Canavalia ensiformis have been studied in mice and rats. The most obvious effect, a lethal tonic convulsion, was generally produced 10-15 min. after intravenous injection of 2-3 mg/kg of the highly purified protein (mol. wt. 88,000). After intraperitoneal, intramuscular or subcutaneous administration the convulsion produced by the same toxin dosis occurred within 24 hours. A spinal transection at… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…