Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine.

@article{Spencer1986CentralMO,
  title={Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine.},
  author={Samuel Spencer and William T Talman},
  journal={Brain research},
  year={1986},
  volume={385 2},
  pages={371-4}
}
We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As previously reported, L-glu and ACh, but not SP elicited dose-dependent arterial hypotension. The data support a putative role for SP in visceral reflexes mediated by vagal nerves. 

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