Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats.

Abstract

The Randomized Aldactone Evaluation Study (RALES) demonstrated a substantial clinical benefit to blocking the effects of aldosterone (Aldo) in patients with heart failure. We recently demonstrated that the enhanced renal conservation of sodium and water in rats with heart failure can be reduced by blocking the central nervous system effects of Aldo with the… (More)

Topics

2 Figures and Tables

Cite this paper

@article{Francis2003CentralMR, title={Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats.}, author={Joseph Francis and Robert M. Weiss and Alan Kim Johnson and Robert B. Felder}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2003}, volume={284 2}, pages={R328-35} }