Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis

@article{Tang2009CentralMI,
  title={Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis},
  author={Yinjie J. Tang and Wenqing Shui and Samuel Myers and Xueyang Feng and Carolyn R Bertozzi and Jay D Keasling},
  journal={Biotechnology Letters},
  year={2009},
  volume={31},
  pages={1233 - 1240}
}
Isotopomer-assisted metabolite analysis was used to investigate the central metabolism of Mycobacterium smegmatis and its transition from normal growth to a non-replicating state under a hypoxic environment. Tween 80 significantly promoted aerobic growth by improving O2 transfer, while only small amount was degraded and metabolized via the TCA cycle for biomass synthesis. As the bacillus encountered hypoxic stress, isotopomer analysis suggested: (1) isocitrate lyase activity increased, which… CONTINUE READING

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