Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-{alpha}-induced apoptosis.

@article{Gupta2005CentralMA,
  title={Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-\{alpha\}-induced apoptosis.},
  author={Sudhir C. Gupta and Ruifen Bi and Sastry V. R. S. Gollapudi},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1050},
  pages={
          108-14
        }
}
Upon activation by antigen, naive T cell subsets undergo proliferation and differentiation into effector cells, followed by the generation of a pool of memory T cells. Based upon migration pattern and functions, they are classified into central memory (predominantly homing to the lymph nodes) and effector memory (predominantly homing to extralymphoid sites) subsets. These subsets are defined phenotypically by a set of cell surface molecules. In this investigation, we demonstrate that naive and… CONTINUE READING
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