Central memory and effector memory T cell subsets: function, generation, and maintenance.

@article{Sallusto2004CentralMA,
  title={Central memory and effector memory T cell subsets: function, generation, and maintenance.},
  author={Federica Sallusto and Jens Geginat and Antonio Lanzavecchia},
  journal={Annual review of immunology},
  year={2004},
  volume={22},
  pages={745-63}
}
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in… CONTINUE READING
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