Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats.

@article{Fuentes1979CentralMO,
  title={Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats.},
  author={Jos{\'e} Antonio Guti{\'e}rrez Fuentes and A Ordaz and Norton H. Neff},
  journal={European journal of pharmacology},
  year={1979},
  volume={57 1},
  pages={21-7}
}
The monoamine oxidase (MAO) inhibitor pargyline induced a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats. The fall of blood pressure correlated with the blockade of norepinephrine (NE) deamination by brain homogenates. After an intracerebroventricular (icv) injection of 6-hydroxydopamine, which lowered brain NE content by about 70%, pargyline was unable to diminish… CONTINUE READING
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