Central mechanisms of hypertension.

  title={Central mechanisms of hypertension.},
  author={Suzanne Oparil and R. H.-H. Yang and Hee Kyung Jin and J. Michael Wyss and Yunjia Chen},
  journal={American journal of hypertension},
  volume={2 6 Pt 1},
Central monoaminergic neurons, particularly noradrenergic neurons, are involved in the pathogenesis of hypertension. Dietary NaCl supplementation in NaCl-sensitive spontaneously hypertensive rats (SHR-S) elevates blood pressure, increases peripheral sympathetic nervous system activity, and depresses endogenous noradrenaline stores and noradrenaline release in the anterior hypothalamus (AHA). NaCl-resistant spontaneously hypertensive rats (SHR-R) and normotensive Wistar-Kyoto (WKY) rats are… CONTINUE READING