Central mechanisms in pain.

  title={Central mechanisms in pain.},
  author={Mark O. Urban and Gerald F. Gebhart},
  journal={The Medical clinics of North America},
  volume={83 3},
Nociceptive input into the central nervous system is not simply passively received but rather is subject to modulation through spinal cord neuroplasticity and descending influences from supraspinal sites activated by a variety of environmental signals, including the acute or persistent nociceptive input itself and behavioral and emotional stimuli. The significant role of NMDA receptors and production of NO. in central sensitization, hyperalgesia, and chronic pain has been demonstrated in… CONTINUE READING
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