Central leptin signalling: beyond the arcuate nucleus.

@article{Jovanovic2010CentralLS,
  title={Central leptin signalling: beyond the arcuate nucleus.},
  author={Z. Jovanovic and Giles S. H. Yeo},
  journal={Autonomic neuroscience : basic & clinical},
  year={2010},
  volume={156 1-2},
  pages={8-14}
}
Leptin is an adipocyte-derived hormone that plays a crucial role in the maintenance of energy balance. Work over the past 15 years has led to a detailed understanding of its signalling and sites of action, particularly its activation of the central melanocortin signalling pathway through the arcuate nucleus of the hypothalamus (ARC). However, leptin receptors are widely expressed throughout the central nervous system (CNS), with leptin acting at distinct sites and through different mechanisms… CONTINUE READING

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