Central leptin regulates the UCP1 and ob genes in brown and white adipose tissue via different beta-adrenoceptor subtypes.

@article{Commins2000CentralLR,
  title={Central leptin regulates the UCP1 and ob genes in brown and white adipose tissue via different beta-adrenoceptor subtypes.},
  author={Scott P Commins and Patricia M. Watson and Nancy Levin and Rudolph J. Beiler and Thomas W Gettys},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 42},
  pages={33059-67}
}
The three known subtypes of beta-adrenoreceptors (beta(1)-AR, beta(2)-AR, and beta(3)-AR) are differentially expressed in brown and white adipose tissue and mediate peripheral responses to central modulation of sympathetic outflow by leptin. To assess the relative roles of the beta-AR subtypes in mediating leptin's effects on adipocyte gene expression, mice with a targeted disruption of the beta(3)-adrenoreceptor gene (beta(3)-AR KO) were treated with vehicle or the beta(1)/beta(2)-AR selective… CONTINUE READING

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