Central leptin modulates behavioral and neural responsivity to CCK.

@article{Emond1999CentralLM,
  title={Central leptin modulates behavioral and neural responsivity to CCK.},
  author={Michael Emond and Gary J Schwartz and Ellen E. Ladenheim and Timothy H. Moran},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1999},
  volume={276 5},
  pages={R1545-R1549}
}
The mechanisms through which leptin, the protein product of the ob gene, affects food intake remain to be determined. To assess whether the actions of leptin depend on modulation of within-meal satiety signals, we measured the effect of third ventricular leptin administration on the satiety actions of CCK. Leptin (10 μg) administered 1 h before 30-min access to a liquid diet had no effect on intake when administered alone, but doses of 3.5 or 10 μg dose dependently increased the suppression of… CONTINUE READING

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