Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats

@article{Scarpace2002CentralLG,
  title={Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats},
  author={Philip J. Scarpace and Michael K. Matheny and Yi Ran Zhang and Nihal T{\"u}mer and Constanza D Frase and Eugene W. Shek and B Hong and Victor Prima and Sergei Zolotukhin},
  journal={Neuropharmacology},
  year={2002},
  volume={42},
  pages={548-561}
}
The purpose of this study was to determine if long-term leptin treatment desensitizes leptin signal transduction and the subsequent downstream anorexic and thermogenic responses in normal and leptin-resistant age-related obese rats. To this end, we administered, i.c.v., recombinant adeno-associated virus encoding rat leptin cDNA (rAAV-leptin) or control virus into young and aged-obese rats and after 9 or 46 days, examined food intake, oxygen consumption, body weight, serum leptin, STAT3… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 57 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Elevated leptin: consequence or cause of obesity?

Frontiers in bioscience : a journal and virtual library • 2007
View 4 Excerpts
Highly Influenced

58 Citations

05'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 58 citations based on the available data.

See our FAQ for additional information.