Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers.


UNLABELLED In most obese patients there is an inflammatory state characterized by lipid abnormalities, hyperleptinemia and hyperinsulinemia. OBJECTIVE The objective was to identify mechanisms involved in leptin's role in the attenuation of the response to insulin using a proteomic approach. MATERIAL/METHODS We studied the serum proteomic profile of rats… (More)
DOI: 10.1016/j.metabol.2012.05.001


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