Central leptin and cholecystokinin in gastroprotection against ethanol-induced damage.

@article{Brzozowski2000CentralLA,
  title={Central leptin and cholecystokinin in gastroprotection against ethanol-induced damage.},
  author={Tomasz Brzozowski and Peter C. Konturek and Stanisław Jan Konturek and Piotr Pierzchalski and Wladyslaw Bielański and Robert Pajdo and Danuta Drozdowicz and Sławomir Kwiecień and Eckhart Georg Hahn},
  journal={Digestion},
  year={2000},
  volume={62 2-3},
  pages={126-42}
}
BACKGROUND Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal integrity. AIMS In this study we compared the effects of leptin and CCK-8 applied intracerebroventricularly (i.c.v.) on gastric secretion and gastric mucosal lesions induced by… CONTINUE READING
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