Central leptin acutely reverses diet-induced hepatic insulin resistance.

  title={Central leptin acutely reverses diet-induced hepatic insulin resistance.},
  author={Alessandro Pocai and Kimyata Morgan and Christoph Buettner and Roger Guti{\'e}rrez-Ju{\'a}rez and Silvana Obici and Luciano Rossetti},
  volume={54 11},
Voluntary overfeeding rapidly induces resistance to the effects of systemic insulin and leptin on liver glucose metabolism. To examine whether central administration of recombinant leptin can restore leptin and insulin action on liver glucose fluxes, we infused leptin in the third cerebral ventricle of conscious overfed rats during pancreatic-insulin clamp studies. The effect of leptin on the phosphorylation of the signal transducer and activator of transcription-3 in the arcuate nuclei of the… CONTINUE READING