Central interleukin-1 beta enhances splenic sympathetic nerve activity in rats.

@article{Ichijo1994CentralIB,
  title={Central interleukin-1 beta enhances splenic sympathetic nerve activity in rats.},
  author={T Ichijo and Toshihiko Katafuchi and T Hori},
  journal={Brain research bulletin},
  year={1994},
  volume={34 6},
  pages={
          547-53
        }
}
The central administration of immune cytokines such as interleukin-1 (IL-1) and interferon-alpha (IFN-alpha) results in the suppression of peripheral cellular immunity, which depends, at least partly, on the sympathetic nervous activity. An intrathird cerebroventricular (I3V) infusion of recombinant human IL-1 beta (rhIL-1 beta) (1-5 ng/rat) elicited a dose-dependent increase in the electrical activity of the splenic sympathetic nerve in urethane and alpha-chloralose anesthetized rats. The… CONTINUE READING

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