Central glucagon-induced hyperglycemia is mediated by combined activation of the adrenal medulla and sympathetic nerve endings.

@article{Amir1986CentralGH,
  title={Central glucagon-induced hyperglycemia is mediated by combined activation of the adrenal medulla and sympathetic nerve endings.},
  author={Shimon Amir},
  journal={Physiology & behavior},
  year={1986},
  volume={37 4},
  pages={563-6}
}
Intracerebroventricular (ICV) microinjection of glucagon (0.0025-2.5 micrograms) produced significant dose-dependent hyperglycemia in mice. This hyperglycemic effect was prevented by pretreatment with the sympathetic ganglionic blocker chlorisondamine chloride or bilateral adrenalectomy plus chemical sympathectomy with 6-hydroxydopamine. Similar pretreatments had no effect on the plasma glucose responses to systemic glucagon administration. Pretreatment with somatostatin, which blocks… CONTINUE READING

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References

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Showing 1-10 of 30 references

Effect of insulin-induced hypoglycemia and glucose-insulin infusion on brain glucagon-like materials in dog

  • H. Kaneda, M. Tominaga, S. Marubashi, T. Kamimura, T. Katagiri, H. Sasaki
  • Biomed Res
  • 1984
1 Excerpt

Intracerebroventricular administration of cholecystokinin-8 elevates plasma pancreatic polypeptide levels in awake dogs

  • Lu, Q.-H, G. H. Greeley, X.-G. Zhu, J. C. Thompson
  • Endocrinology
  • 1984
1 Excerpt

Glucagon and liver glucose output in vivo

  • J. L. Chiasson, A. D. Cherrington
  • Handbook Exp Pharmacol
  • 1983
1 Excerpt

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