Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats.

@article{AlBarazanji2000CentralEI,
  title={Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats.},
  author={Kamal A Al-Barazanji and Jonathan R.S Arch and Robin E Buckingham and Mohammad Tadayyon},
  journal={Obesity research},
  year={2000},
  volume={8 4},
  pages={317-23}
}
OBJECTIVE To investigate whether chronic administration of the long-acting glucagon-like peptide-1 receptor agonist exendin-4 can elicit sustained reductions in food intake and body weight and whether its actions require an intact leptin system. RESEARCH METHODS AND PROCEDURES Male lean and obese Zucker (fa/fa) rats were infused intracerebroventricularly with exendin-4 using osmotic minipumps for 8 days. RESULTS Exendin-4 reduced body weight in both lean and obese Zucker rats, maximum… CONTINUE READING